CLONING OF A CANCER CELL–PRODUCING HEPATOCYTE GROWTH FACTOR, VASCULAR ENDOTHELIAL GROWTH FACTOR, AND INTERLEUKIN-8 FROM GASTRIC CANCER CELLS

MINEKO IWAI; MASAHIKO MATSUDA; YOSHIAKI IWAI

doi:10.1290/1543-706X(2003)039<0288:COACCH>2.0.CO;2

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MINEKO IWAI,^1,* MASAHIKO MATSUDA,¹ YOSHIAKI IWAI¹

¹Department of Applied Bio-Science, Research Institute for Advanced Science and Technology, Osaka Pre

^*To whom correspondence should be addressed at iwaimi@riast.osakafu-u.ac.jp

Abstract

A cell colony (IM95m) that produces hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and interleukin-8 (IL-8) was cloned from gastric cancer cells (IM95 cell line). In culture medium, the highest levels of HGF, VEGF, and IL-8 were about 1.1, 0.9, and 0.17 ng/ml culture medium at 3 d from 10⁵ cells. IM95m may be useful in elucidating the role of tumor cells in angiogenesis.

Citation Download Citation

MINEKO IWAI, MASAHIKO MATSUDA, and YOSHIAKI IWAI "CLONING OF A CANCER CELL–PRODUCING HEPATOCYTE GROWTH FACTOR, VASCULAR ENDOTHELIAL GROWTH FACTOR, AND INTERLEUKIN-8 FROM GASTRIC CANCER CELLS," In Vitro Cellular & Developmental Biology - Animal 39(7), 288-290, (1 July 2003). https://doi.org/10.1290/1543-706X(2003)039<0288:COACCH>2.0.CO;2

Received: 15 July 2003; Accepted: 1 November 2003; Published: 1 July 2003